Read about symptoms and risk factors below. Open this handy dental health tool to bring to your dentist appointments. Call your doctor if you have any stiffness, twitching, spasms, or cramps in your muscles. If you have a history of broken bones fractures or osteoporosis, your risk may be higher. Sign up here. Your bones are constantly changing, always breaking down and rebuilding to stay strong. Tap on the tabs below to learn more. At Half of people had not experienced a serious bone problem at: Serious bone problems cause many women with breast cancer to feel pain More than 4 out of 5 women with a serious bone problem experienced bone pain.
Denosumab has not been studied for use by children and adolescents who have other cancers that have spread to bone. If you are taking any of these medications, speak with your doctor or pharmacist. Depending on your specific circumstances, your doctor may want you to:. An interaction between two medications does not always mean that you must stop taking one of them.
Speak to your doctor about how any drug interactions are being managed or should be managed. Medications other than those listed above may interact with this medication.
Tell your doctor or prescriber about all prescription, over-the-counter non-prescription , and herbal medications you are taking. Also tell them about any supplements you take.
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Let's get started. Acne Doctor Discussion Guide. Acne: Fact vs Myth Quiz. Acne Treatment Options Table. Contact your health care provider immediately, day or night, if you should experience the following:.
Always inform your health care provider if you experience any unusual symptoms. You will be checked regularly by your doctor while you are taking Xgeva, to monitor side effects and check your response to therapy. Periodic blood work will be obtained to monitor the function of your organs such as your kidneys and liver , as deemed necessary by your doctor.
Cancer cells that spread to the bone can secrete substances that can cause cells in the bone called osteoclasts to dissolve or "eat away" a portion of the bone. The process, during which osteoclasts break down bone and then release those minerals such as calcium from bone fluid into the blood, is called "bone resorption".
These tumors or lesions in the bone weaken the bone and can lead to complications, referred to as "skeletal related events. RANKL affects the activity of osteoclasts. Osteoclasts help with normal bone breakdown activity to regulate calcium levels. In women diagnosed with breast cancer that has spread to the bones, osteoclasts tend to be overactive. These overactive osteoclasts can cause bone pain and bone destruction. By limiting osteoclast activity, Xgeva can lessen pain and reduce the risk of bone problems for these women.
Under the brand name Prolia, denosumab is approved by the FDA to treat postmenopausal women diagnosed with osteoporosis who are at high risk of breaking a bone or who can't take or haven't gotten any benefit from other osteoporosis treatments. Prolia treats osteoporosis by restoring the delicate balance of bone building and bone breakdown.
While Prolia and Xgeva are made of the same chemical components, each is used for a different purpose. Some possible side effects of Xgeva and Prolia include back, arm, and leg pain; high cholesterol levels; and urinary infections.
In addition to osteonecrosis of the jaw, more serious but much less common side effects include low blood calcium levels, rashes, and severe infections.
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